| Autor: |
E.K. You-Ten, Valerie B. Caraiscos, Victor Y. Cheng, B.A. Orser, J.G. Newell, John F. MacDonald |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
International Congress Series. 1283:189-192 |
| ISSN: |
0531-5131 |
| Popis: |
The volatile anesthetic, isoflurane, potentiates and inhibits GABAA receptors (GABAARs)function at low and high concentrations, respectively. We examined whether the α subunit isoform influences isoflurane inhibition by studying currents generated by human recombinant α5/1β3γ2L GABAARs. The subunit isoforms selected for the study mediate a tonic (α5) and synaptic (α1) inhibitory conductance in hippocampal pyramidal neurons. The α5 subunit conferred partial resistance to isoflurane blockade compared with the α1 subunit. The steady-state current was preferentially reduced compared with the peak current suggesting that isoflurane inhibited GABAAR function by stabilizing an agonist-bound, closed conformational state or by a use-dependent steric blocking mechanism. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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