Total synthesis of 4-epi-atpenin A5 as a potent nematode complex II inhibitor

Autor:	Kento Takahashi, Yui Kuwayama, Satoshi Omura, Tohru Nagamitsu, Masaki Ohtawa, Hiroki Kondo, Daiki Lee, Shiho Arima
Rok vydání:	2019
Předmět:	Nematode biology Biochemistry Chemistry parasitic diseases Organic Chemistry Drug Discovery Total synthesis biology.organism_classification Atpenin A5
Zdroj:	Tetrahedron. 75:3178-3185
ISSN:	0040-4020
DOI:	10.1016/j.tet.2019.02.050
Popis:	It is clear that atpenins and their analogs are useful chemical tools for elucidation of complex II functionality and that they could act as lead compounds for the development of novel helminth complex II-specific inhibitors. Recently, we discovered 4-epi-atpenin A5 as a potent nematode complex II inhibitor during our SAR studies of atpenin A5. This result led us to embark on a concise total synthesis of 4-epi-atpenin A5. In this study, we describe the total synthesis of 4-epi-atpenin A5. Importantly, this was more concise and practical synthesis than our previous total synthesis of atpenin A5.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::89fb6d420bc91b8ec2cabb9731d2abbc https://doi.org/10.1016/j.tet.2019.02.050 Zobrazit plný text záznamu Full Text from ScienceDirect