Oxygen Production of Modified Core–Shell CuO@ZrO2 Nanocomposites by Microwave Radiation to Alleviate Cancer Hypoxia for Enhanced Chemo-Microwave Thermal Therapy
| Autor: | Ke Xu, Meng Niu, Xianwei Meng, Hongshan Zhong, Zengzhen Chen, Qiong Wu, Gen Chen, Changhui Fu, Xiangling Ren, Longfei Tan |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Nanocomposite General Engineering Oxygen evolution General Physics and Astronomy chemistry.chemical_element 02 engineering and technology Polyethylene glycol 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Oxygen 0104 chemical sciences chemistry.chemical_compound chemistry Chemical engineering Hexafluorophosphate medicine General Materials Science Doxorubicin 0210 nano-technology Mesoporous material Microwave medicine.drug |
| Zdroj: | ACS Nano. 12:12721-12732 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/acsnano.8b07749 |
| Popis: | There are acknowledged risks of metastasis of cancer cells and obstructing cancer treatment from hypoxia. In this work, we design a multifunctional nanocomposite for treating hypoxia based on the oxygen release capability of CuO triggered by microwave (MW). Core–shell CuO@ZrO2 nanocomposites are prepared by confining CuO nanoparticles within the cavities of mesoporous ZrO2 hollow nanospheres. 1-Butyl-3-methylimidazolium hexafluorophosphate (IL) is loaded to the CuO@ZrO2 nanocomposites for improving microwave thermal therapy (MWTT). 1-Tetradecanol (PCM) is introduced to regulate the release of chemotherapeutic drugs of doxorubicin (DOX). Thus, the IL-DOX-PCM-CuO@ZrO2 multifunctional (IDPC@Zr) nanocomposites are obtained. Finally, IDPC@Zr nanocomposites are modified by monomethoxy polyethylene glycol sulfhydryl (mPEG-SH, 5 kDa) (IDPC@Zr-PEG nanocomposites). IDPC@Zr-PEG nanocomposites can produce oxygen in the tumor microenvironment during the course of tumor treatment, thereby alleviating the hypoxic state ... |
| Databáze: | OpenAIRE |
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