Antimicrobial activity of a novel furan fatty acid, 7,10-epoxyoctadeca-7,9-dienoic acid against methicillin-resistant Staphylococcus aureus
| Autor: | Joel B. Ellamar, Young Soon Kim, Hak-Ryul Kim, Chakradhar Dasagrandhi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification 030106 microbiology Broth microdilution Fatty acid biochemical phenomena metabolism and nutrition Biology bacterial infections and mycoses medicine.disease_cause Antimicrobial Applied Microbiology and Biotechnology Methicillin-resistant Staphylococcus aureus Microbiology 03 medical and health sciences chemistry.chemical_compound Minimum inhibitory concentration 030104 developmental biology chemistry Furan medicine Bioassay Coagulase Food Science Biotechnology |
| Zdroj: | Food Science and Biotechnology. 25:1671-1675 |
| ISSN: | 2092-6456 1226-7708 |
| Popis: | We analyzed the antimicrobial potential of a novel furan fatty acid, 7,10-epoxyoctadeca-7,9-dienoic acid (7,10-EODA) against methicillin-resistant and -sensitive S. aureus (MRSA and MSSA). The anti-staphylococcal activity of 7,10-EODA and its consequences on cell physiology was determined by disc diffusion, broth microdilution, and flow cytometry. Anti-virulence activity of 7,10-EODA was evaluated by bioassays. 7,10-EODA was anti-staphylococcal with minimum inhibitory concentration (MIC) range of 125-250 mg/L. 7,10-EODA exhibited a dose response and inhibited MRSA 01ST001 by 90.5% and ATCC 29213 (MSSA) by 85.3% at 125 mg/L. MIC of 7,10-EODA permeabilized >95 % of MRSA 01ST001 cells to small molecules. Sublethal dose of 7,10-EODA was non-toxic but markedly reduced the hemolytic, coagulase, and autolytic activities of MRSA and MSSA at 15.6 mg/L. The results provide a lead for the utilization of natural furan fatty acids as novel anti-MRSA agents. |
| Databáze: | OpenAIRE |
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