Synthesis and Transformations of 4-Hydroxy-2-methylquinoline-6-carbohydrazide

Autor:	I. L. Aleksanyan, L. P. Hambardzumyan
Rok vydání:	2019
Předmět:	Carbon disulfide 010405 organic chemistry Phenyl isothiocyanate Organic Chemistry Hydrazine Triazole Intramolecular cyclization Carbohydrazide 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Reagent Hydrate
Zdroj:	Russian Journal of Organic Chemistry. 55:262-265
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428019020209
Popis:	A substituted quinoline-6-carbohydrazide was synthesized by the reaction of ethyl 4-hydroxy-2-methylquinoline-6-carboxylate with hydrazine hydrate. The quinoline-6-carbohydrazide was reacted with phenyl isothiocyanate to obtain the corresponding phenylhydrazinecarbotioamide. The intramolecular cyclization of the latter in alkaline and acidic media gave quinolyl-substituted triazole and thiadiazole. The reaction of the quinoline-6-carbohydrazide with carbon disulfide in an alkaline media yielded a quinolyl-substituted 1,3,4-oxadiazole, and the reactions of the same reagent with substituted benzaldehydes gave N′-(substituted benzylidene)quinoline-6-carbohydrazides.
Databáze:	OpenAIRE
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