Pharmacokinetics of intravenous and oral metformin and r,s-verapamil in Sinclair, Hanford, Yucatan and Göttingen minipigs
| Autor: | David T. White, Naijia Huang, Jeffrey S. Tan, Kenneth J. Ruterbories, Jason Liu, Derek Brocksmith, Lee J. Burns, Alain Stricker-Krongrad, Nathan Yumibe, Nita J. Patel, Guy Bouchard |
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| Rok vydání: | 2017 |
| Předmět: |
Plasma clearance
genetic structures 040301 veterinary sciences business.industry 04 agricultural and veterinary sciences Pharmacology 030226 pharmacology & pharmacy eye diseases Bioavailability Metformin 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Medicine Verapamil business medicine.drug |
| Zdroj: | International Journal of Pharmacokinetics. 2:81-91 |
| ISSN: | 2053-0854 2053-0846 |
| Popis: | Aim: Oral and intravenous pharmacokinetic (PK) studies were conducted in four different minipig strains: Sinclair, Yucatan, Hanford and Göttingen after administration of metformin or R,S-verapamil (R,S-VER). Results: The results indicated that the PK of metformin was similar between all minipig strains, except for the Göttingen which had higher plasma clearance. The plasma clearance of both (+)-(R)- and (−)-(S)-VER was significantly lower in Sinclair compared with the clearance in other strains. The (+)-(R)-NOR to R,S-VER ratio was significantly higher in the Sinclair. There was a preferential conversion of R,S-VER to (+)-(R)-NOR over (−)-(S)-NOR in all minipig strains. Conclusion: This work highlights the importance of considering the impact of metabolic and dispositional differences in minipig strains when conducting PK studies. |
| Databáze: | OpenAIRE |
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