Detection of SARS-CoV-2 Antibodies in Matched Pregnant Women and Newborn Blood
| Autor: | Zeliha Haytoglu, Eren Haytoglu, Ferda Ozlu, Hacer Yapıcıoglu Yıldızdas, Filiz Kibar, Salih Çetiner, Selvi Gulası, Gulsum Uysal, Ozlem Ozgur Gundeslioglu, Derya Alabaz, Mete Sucu, Umit Celik |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Pediatric Infectious Diseases. |
| ISSN: | 1305-7693 1305-7707 |
| DOI: | 10.1055/s-0043-1768200 |
| Popis: | Objective The factors affecting the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies from mother to newborn and the duration of seropositivity rates in these infants have not yet been clearly demonstrated. The objectives of this study were (1) to assess the levels of SARS-CoV-2 spike–specific immunoglobulin G (IgG) in women infected in the pregnancy period and newborns born to these women and (2) to search the transplacental transfer ratio of spike-specific IgG. Methods Seventy pregnant women with symptomatic SARS-CoV-2 infection and their newborns were prospectively followed. Anti–SARS-CoV-2 immunoassay was used for the detection of the in vitro quantitative determination of total antibodies to the SARS-CoV-2 spike protein. Discussion Spike-specific IgG was demonstrated in 89.1% (44 of 46) of pregnant women infected more than 14 days before delivery and in 92.6% (43 of 44) of their newborns. Median transfer ratio of spike-specific Ig was 0.87 (interquartile range [IQR], 0.34–0.90), 1.0 (IQR, 0.9–0.29), and 0.81 (IQR, 0.02–1.0) in first trimester (n = 4), second trimester (n = 14), and third trimester (n = 28) pregnant women, respectively. Antibody transfer ratio was correlated with time elapsed from infection (p Conclusion Timing from infection to delivery and severity of maternal infection are critical in assessing the antibody generation and transport. Higher antibody transfer ratio can be detected in neonates when SARS-CoV-2 infection is present for more than 60 days before birth. Maternally derived antibody can persist for 3 months after birth. |
| Databáze: | OpenAIRE |
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