Procalcitonin and other inflammatory markers in patients with sepsis and septic shock: A single-center experience

Autor:	Sumaira Rafiqui, Saibu George, Muna Al Maslamani, Abdel-Naser Elzouki, Merlin Thomas
Rok vydání:	2019
Předmět:	medicine.medical_specialty biology business.industry Critically ill Septic shock C-reactive protein bacterial infections and mycoses Single Center medicine.disease Procalcitonin Sepsis Internal medicine biology.protein Medicine In patient General hospital business hormones hormone substitutes and hormone antagonists
Zdroj:	Ibnosina Journal of Medicine and Biomedical Sciences. 11:176-180
ISSN:	1947-489X
DOI:	10.4103/ijmbs.ijmbs_64_19
Popis:	Objective: The objective of the study was to compare the diagnostic value of serum procalcitonin (PCT), C-reactive protein (CRP), lactic acid, and white blood cells (WBC) as markers of sepsis in critically ill patients in the main tertiary hospital in Qatar. Materials and Methods: The PCT levels and other inflammatory markers (CRP, lactic acid, and WBC) were retrospectively reviewed in 137 consecutive adult patients with a suspected diagnosis of sepsis who admitted to the Internal Medicine inpatient service (i.e., Medical Wards and Medical Intensive Care Unit) at Hamad General Hospital, Qatar. The serum PCT was measured by chemiluminescence immunoassay and the results were compared with commonly used inflammatory markers between the patients with and without proven sepsis. Results: A significantly higher PCT level was observed among patients with severe sepsis and septic shock compared to those without sepsis (19.34 ± 50 and 25.91 ± 61.3 vs. 4.72 ± 10, respectively; P = 0.011). No significant differences were found in CRP and WBC between these groups. Nonsurvivors of both septic and nonseptic groups had a mean PCT level of 22.48 ± 8.26 significantly higher than that measured in survivors of both the groups (P = 0.01), a difference not evident in other inflammatory parameters. Conclusions: PCT is a highly efficient inflammatory laboratory parameter for the diagnosis of severe sepsis and septic shock, but WBC and CRP levels were of little value. PCT value assists in the diagnosis of septic shock, hence supporting appropriate disposition of patients. The levels of PCT also have prognostic implications with regard to mortality suggesting intensification of antibiotic therapy and supportive measures including appropriate family counseling.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::89e319655f09a9d385b801aaea95db92 https://doi.org/10.4103/ijmbs.ijmbs_64_19 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.