Magnitude, short-term outcomes and risk factors for hypoxic ischemic encephalopathy at abha maternity and children hospital, Abha City, Saudi Arabia and literature review

Autor:	Rania H Albar, Amal A Khormi, Mufareh H M. Almazkary, Ahmad A Alzoani, Raja M Thigha
Rok vydání:	2020
Předmět:	Mechanical ventilation Pediatrics medicine.medical_specialty business.industry Neonatal encephalopathy medicine.medical_treatment Encephalopathy Hypoxia (medical) medicine.disease Hypoxic Ischemic Encephalopathy Pediatrics Perinatology and Child Health medicine medicine.symptom business Positive pressure ventilation Clinical syndrome
Zdroj:	Journal of Clinical Neonatology. 9:98
ISSN:	2249-4847
DOI:	10.4103/jcn.jcn_12_19
Popis:	Background: When hypoxia is the cause for neonatal encephalopathy, a clinical syndrome has been described known as hypoxic–ischemic encephalopathy (HIE). Aim of the Study: This study aimed to determine the magnitude of HIE occurrence, its short-term outcomes, and associated risk factors. Literature review was included for comparing our reported findings with other published ones. Methods: A retrospective, case–control study was conducted at “Abha Maternity and Children Hospital” (AMCH) that included all inborn term and late-preterm newborns with the “admission diagnosis” of HIE during 2016–2017. Healthy newborn babies were taken as controls. Data were extracted from neonatal medical files for HIE cases and maternal medical files for the controls. Results: Of 15,790 livebirths, 124 cases had HIE (7.85/1000 livebirths), of whom 3.98/1000 and 3.86/1000 livebirths were staged as mild and moderate-to-severe HIE, respectively. Short-term outcomes for HIE were 14 deaths (11.3%) and 33 cases with seizures (26.6%), which occurred exclusively among moderate–severe HIE cases; 87 cases (70.2%) required positive pressure ventilation, and 45 cases (36.3%) required mechanical ventilation, with significantly higher rate among moderate–severe HIE than mild cases (P
Databáze:	OpenAIRE
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