Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice

Autor: Yohan S. S. Auguste, Austin Ferro, Jessica A. Kahng, Andre M. Xavier, Jessica R. Dixon, Uma Vrudhula, Anne-Sarah Nichitiu, Daniele Rosado, Tse-Luen Wee, Ullas V. Pedmale, Lucas Cheadle
Rok vydání: 2022
Předmět:
Zdroj: Nature Neuroscience. 25:1273-1278
ISSN: 1546-1726
1097-6256
DOI: 10.1038/s41593-022-01170-x
Popis: Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPCs are not limited to oligodendrogenesis. Here we show that OPCs contribute to thalamocortical presynapse elimination in the developing and adult mouse visual cortex. OPC-mediated synapse engulfment increases in response to sensory experience during neural circuit refinement. Our data suggest that OPCs may regulate synaptic connectivity in the brain independently of oligodendrogenesis.
Databáze: OpenAIRE
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