Ovarian cancer in infertile women during or after ovulation-inductiontherapy: expression of LH/hCG receptors and sex steroid receptors

Autor: Masaki Mandai, Takehiko Mori, Ch.V. Rao, Ikuo Konishi, Kanako Nanbu, Hideki Kuroda
Rok vydání: 1997
Předmět:
Zdroj: International Journal of Gynecological Cancer. 7:451-457
ISSN: 1525-1438
1048-891X
DOI: 10.1046/j.1525-1438.1997.09753.x
Popis: Kuroda H, Konishi I, Mandai M, Nanbu K, Rao Ch V, Mori T. Ovarian cancer in infertile women during or after ovulation-induction therapy: expression of LH/hCG receptors and sex steroid receptors. Int J Gynecol Cancer1997; 7: 451–457. A possible association between the use of fertility drugs and development of ovarian cancer has recently been suggested. Review of 131 patients with ovarian carcinoma in our hospital revealed that six (4.6%) cases had developed during or after ovulation-induction therapy. To examine the hormone sensitivity of these tumors, the expression of luteinizing hormone/chorionic gonadotropin (LH/hCG) receptors and sex steroid receptors in the tumor cells was analyzed by immunohistochemistry. In addition, to elucidate the clinical and pathological characteristics of ovarian cancer in this setting, all of the 41 cases, including both of our series and previously reported cases in the literature, were reviewed. Immunohistochemical analysis showed that expression of LH/hCG receptors or sex steroid receptors in the tumor cells was observed in five of the six cases. This suggests that gonadotropins and/or sex steroids may influence the biological behavior of the tumor. Ovarian cancer during or after ovulation-induction consisted of two different types: one is serous, low-malignant potential (LMP) or invasive carcinoma and the other is endometrioid or clear cell carcinoma arising in an endometriotic cyst. Although the latter group is usually detected at an early stage, serous tumors are frequently at an advanced stage, even under close examination during infertility treatment. This is essential for giving informed consent during ovulation-induction therapy for infertile women.
Databáze: OpenAIRE
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