Infrared Spectroscopy of Blood Serum from Patients with Oncohematological Diseases
| Autor: | A. Yu. Kuvshinov, E. A. Telnaya, Andrey Garifullin, A. M. Polyanichko, L. V. Plotnikova, SV Voloshin |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030102 biochemistry & molecular biology business.industry Chronic lymphocytic leukemia Biophysics Infrared spectroscopy medicine.disease Gastroenterology 03 medical and health sciences 030104 developmental biology Blood serum hemic and lymphatic diseases Internal medicine medicine In patient business Protein secondary structure Multiple myeloma |
| Zdroj: | Biophysics. 65:981-986 |
| ISSN: | 1555-6654 0006-3509 |
| DOI: | 10.1134/s0006350920060214 |
| Popis: | A comparative analysis of the secondary structure of blood serum proteins was carried out in patients with multiple myeloma, chronic lymphocytic leukemia and in healthy donors. The secondary structure of proteins in serum was determined using an infrared spectroscopy method. It was demonstrated that the proposed approach allows one to register a decrease in the portion of α-helical regions and an increase in the number of β-sheets in the blood serum samples of patients with multiple myeloma compared with healthy donors and patients with chronic lymphocytic leukemia. |
| Databáze: | OpenAIRE |
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