| Autor: |
Stott, David J, Rodondi, Nicolas, Kearney, Patricia M, Ford, Ian, Westendorp, Rudi GJ, Mooijaart, Simon P, Sattar, Naveed, Aubert, Carole E, Aujesky, Drahomir, Bauer, Douglas C, Baumgartner, Christine, Blum, Manuel R, Browne, John P, Byrne, Stephen, Collet, Tinh-Hai, Dekkers, Olaf M, Den Elzen, Wendy PJ, Du Puy, Robert S, Ellis, Graham, Feller, Martin, Floriani, Carmen, Hendry, Kirsty, Hurley, Caroline, Jukema, J Wouter, Kean, Sharon, Kelly, Maria, Krebs, Danielle, Langhorne, Peter, McCarthy, Gemma, McCarthy, Vera, McConnachie, Alex, McDade, Mairi, Messow, Martina, O'Flynn, Annemarie, O'Riordan, David, Poortvliet, Rosalinde KE, Quinn, Terence J, Russell, Audrey, Sinnott, Carol, Smit, Jan WA, Van Dorland, H Anette, Walsh, Kieran A, Walsh, Elaine K, Watt, Torquil, Wilson, Robbie, Gussekloo, Jacobijn, TRUST Study Group |
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| Popis: |
BACKGROUND: The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition. METHODS: We conducted a double-blind, randomized, placebo-controlled, parallel-group trial involving 737 adults who were at least 65 years of age and who had persisting subclinical hypothyroidism (thyrotropin level, 4.60 to 19.99 mIU per liter; free thyroxine level within the reference range). A total of 368 patients were assigned to receive levothyroxine (at a starting dose of 50 μg daily, or 25 μg if the body weight was |
| Databáze: |
OpenAIRE |
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