L'azione Del 5-Bis(2-Cloroetil)Aminouracile Sul Sangue E Sui Tessuti Emolinfopoietici Normali

Autor:	Scaltrini Gc, Conigliaro S
Rok vydání:	1961
Předmět:	03 medical and health sciences Cancer Research 0302 clinical medicine Oncology Action (philosophy) Chemistry 030220 oncology & carcinogenesis Blood pharmacology General Medicine Pharmacology 030226 pharmacology & pharmacy
Zdroj:	Tumori Journal. 47:245-260
ISSN:	2038-2529 0300-8916
DOI:	10.1177/030089166104700306
Popis:	Uracil mustard was administered at different dosage levels to albino mice and the effects on peripheral blood, bone marrow and spleen cells quantitated. At low dosage levels (0,0125 and 0,050 mg/kg/die for 5 days) decrease of circulating (mainly polinucleated) leukocytes was the only effect observed at 24 hrs. after the end of the treatment. Higher doses (0,200 and 0,800 mg/kg/die for 5 days) produced remarkable hypoplasia of the hemolymphopoietic tissues and a slight decrease in body and kidney weight. Eleven days after the end of the treatment the lymphoid and megakaryocytic hypoplasia was reduced and all the other observed lesions were repaired.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::89c3be7b9bf038bac397b58f437063d3 https://doi.org/10.1177/030089166104700306 Zobrazit plný text záznamu