Radical cyclization; towards the syntheses of tetranor metabolites of 15-F2t-isoprostane

Autor:	Alexandre Guy, Thierry Durand, Olivier Henry, Jean-Pierre Vidal, Arlene Roland, Jean-Claude Rossi
Rok vydání:	2003
Předmět:	chemistry.chemical_compound 15-F2t-isoprostane Isoprostane chemistry Radical Organic Chemistry Drug Discovery Wittig reaction Organic chemistry Cyclopentane Biochemistry Radical cyclization Coupling reaction
Zdroj:	Tetrahedron. 59:2485-2495
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(03)00258-8
Popis:	Radical cyclization of acyclic 1-substituted-2,4-dihydroxylated 5-hexenyl radicals produced functionalized cyclopentane derivatives. These cyclopentanic precursors after different protection/deprotection reactions followed by Wittig and Horner–Wadsworth–Emmons coupling reactions led to the main urinary tetranor metabolites of 15-F 2t -isoprostane (8- epi -PGF 2α ).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::89c37e1a898a9f2bd30f60eb32b18b20 https://doi.org/10.1016/s0040-4020(03)00258-8 Zobrazit plný text záznamu Full Text from ScienceDirect