Verbesserte Synthese vonN1-Pyridylthiaminpyrophosphat, einem coenzymatisch aktiven Analogon des Thiaminpyrophosphates

Autor:	Ralph Golbik, Holger Neef, Barbel Fahlbusch, Alfred Schellenberger
Rok vydání:	1990
Předmět:	biology Stereochemistry Organic Chemistry Ion chromatography Pyrophosphate Cofactor chemistry.chemical_compound chemistry Sephadex Yield (chemistry) biology.protein Thiamine Pyridinium Physical and Theoretical Chemistry Thiamine pyrophosphate
Zdroj:	Liebigs Annalen der Chemie. 1990:913-916
ISSN:	1099-0690 0170-2041
DOI:	10.1002/jlac.1990199001167
Popis:	Improved Synthesis of N1-Pyridylthiamine Pyrophosphate, a Coenzymatically Active Analog of Thiamine Pyrophosphate Our previously published synthesis of the N1-pyridyl analog 1b of thiamine pyrophosphate6) is improved resulting in a remarkably higher yield. Key reaction of this new synthetic pathway is the oxidative degradation of 5-acetylpyridine 8 to the 5-carboxylic acid 11 via the pyridinium compound 10. Improved preparations of other intermediates are also described. The N1-pyridylthiamine pyrophosphate analog 1b has been separated and purified by ion exchange chromatography on Sephadex A-25.
Databáze:	OpenAIRE
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