Synthesis, Properties, Analgesic and Anti-Inflammatory Activity, And Hemostatic Effect of 4-Acyl-1-(2-Aminopropyl)- 5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones and their Derivatives
| Autor: | N. N. Kasimova, A. V. Starkova, S. V. Chashchina, V. L. Gein, B. Ya. Syropyatov |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
chemistry.chemical_classification 010405 organic chemistry Chemistry medicine.drug_class Aryl Hydrazine Analgesic Pharmacology toxicology Antimicrobial 01 natural sciences Aldehyde Anti-inflammatory 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Acetic anhydride Drug Discovery medicine Organic chemistry |
| Zdroj: | Pharmaceutical Chemistry Journal. 53:701-705 |
| ISSN: | 1573-9031 0091-150X |
| Popis: | A series of 1-(2-aminopropyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by three-component reactions of 4-substituted 2,4-dioxobutanoic acid methyl esters with mixtures of an aromatic aldehyde and 1,2-diaminopropane. Products of their reactions with hydrazine, p-phenetidine, and acetic anhydride were obtained. The analgesic, anti-inflammatory, and antimicrobial activities and hemostatic effect of several compounds were studied. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink