Detect-to-treat: development of analysis of bacilli spores in nasal mucus by surfaced-enhanced Raman spectroscopy
| Autor: | Frank Inscore, Alan D. Gift, Stuart Farquharson |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Bacilli
Materials science biology fungi Surface-enhanced Raman spectroscopy biology.organism_classification Dipicolinic acid humanities Microbiology Bacillus anthracis Spore chemistry.chemical_compound symbols.namesake chemistry Nasal Swab Nasal mucus symbols Raman spectroscopy Biomedical engineering |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| Popis: | As the war on terrorism in Afghanistan and Iraq continue, future attacks both abroad and in the U.S.A. are expected. In an effort to aid civilian and military personnel, we have been investigating the potential of using a surface-enhanced Raman spectroscopy (SERS) sampling device to detect Bacillus anthracis spores in nasal swab samples. Such a device would be extremely beneficial to medical responders and management in assessing the extent of a bioterrorist attack and making detect-to-treat decisions. The disposable sample device consists of a glass capillary filled with a silver-doped sol-gel that is capable of extracting dipicolinic acid (DPA), a chemical signature of Bacilli, and generating SERS spectra. The sampling device and preliminary measurements of DPA extracted from spores and nasal mucus will be presented. |
| Databáze: | OpenAIRE |
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