Squamous cell carcinoma of the anal canal at The Queen Elizabeth Hospital: A local experience

Autor: Nicholas A. Rieger, Jasiah Zakaria, Ken Pittman, Martin Borg, K. Patterson, Timothy J. Price, Jacqueline H. Stephens, Ganessan Kichenadasse, Peter J. Hewett, David J Rodda
Rok vydání: 2007
Předmět:
Zdroj: Asia-Pacific Journal of Clinical Oncology. :071011204603003
ISSN: 1743-7563
1743-7555
DOI: 10.1111/j.1743-7563.2007.00115.x
Popis: Aim: Concurrent chemoradiotherapy is the standard treatment for squamous cell carcinoma of anal canal. We describe our experience of treating such patients at our center. Methods: Patients with anal squamous cell carcinoma were treated with a uniform sphincter preserving protocol at The Queen Elizabeth Hospital, South Australia. Standard radiotherapy along with 5-fluorouracil (750 mg/m2 on days 1–5 and days 29–32) and mitomycin C (12 mg/m2 on day 1 only) was given to eligible patients. Results: Of the 34 patients included in this study, nearly 60% were women. Most (89.3%) had T1-2 disease. One-third had nodal involvement. Twenty-seven had chemoradiotherapy, six had local excision alone and one had radiotherapy alone. Among those who had chemoradiation, 71.5% had a complete response and remained colostomy free until the last follow-up. Most completed the treatment without major side-effects. The 3 and 5-year disease free survival rate was 62% and 53%, respectively. All patients who failed chemoradiation underwent salvage surgery with a median survival time of 32.5 months. Conclusion: Sphincter preservation is the goal for anal cancers. Chemoradiotherapy is an important modality to achieve this goal.
Databáze: OpenAIRE
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