pKa Determination of Carvedilol by Spectrophotometry
| Autor: | Job Herman Berkhout, Mahalaxmi Rathnanand, H.N. Aswatha Ram |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.diagnostic_test
Chemistry 010401 analytical chemistry Thermodynamics Value (computer science) 030226 pharmacology & pharmacy 01 natural sciences 0104 chemical sciences 03 medical and health sciences 0302 clinical medicine Spectrophotometry medicine Pharmacology (medical) Pharmacology Toxicology and Pharmaceutics (miscellaneous) Carvedilol medicine.drug |
| Zdroj: | Research Journal of Pharmacy and Technology. :2714-2716 |
| ISSN: | 0974-360X 0974-3618 |
| Popis: | Proper knowledge of the pKa value of a compound is of uttermost importance for understanding the behavior of a drug inside the body. The pKa value of Nonselective alpha-1 and beta-blocker Carvedilol shows controversies in literature, whereas values between 7.7 and 8.7 have been previously reported. In this research paper, the pKa value of Carvedilol was re-evaluated using UV-vis spectroscopy. The analytical wavelength used was 241nm. The obtained sigmoid pattern was non-linear fitted using the Boltzmann sigmoidal algorithm. The determined pKa was 7.77 ± 0.09. This value is in accordance with some of the literature publications. Since extensive statistics and multiple replicate experiments were performed, it is assumed that 7.8 is the true pKa value of Carvedilol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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