Synthesis of Laminarin Fragments and Evaluation of a β-(1,3) Glucan Hexasaccaride-CRM197Conjugate as Vaccine Candidate againstCandida albicans

Autor:	Maria Rosaria Romano, Elisa Danieli, Marta Tontini, Gabriele Costantini, Francesco Berti, Daniela Proietti, Paolo Costantino, Roberto Adamo, Giulia Brogioni
Rok vydání:	2011
Předmět:	chemistry.chemical_classification Antigenicity biology Chemistry Glycoconjugate Organic Chemistry Random hexamer biology.organism_classification Biochemistry Laminarin chemistry.chemical_compound biology.protein sense organs Antibody Candida albicans Glucan Conjugate
Zdroj:	Journal of Carbohydrate Chemistry. 30:249-280
ISSN:	1532-2327 0732-8303
Popis:	Laminarin-CRM197 glycoconjugates were previously demonstrated to be immunogenic and confer protection against Candida albicans in mice. Laminarin consists of β-(1,3) glucan repeating units, with sporadic β-(1,6) branches. A set of short glucans was used to study the effect of the β-(1,6) branch on the antigenicity of linear β-(1,3) glucans. A linear β-(1,3) glucan hexasaccharide was selected as the best fragment able to inhibit the binding between laminarin and antilaminarin antibodies. The hexamer was then conjugated to CRM197 and induced, in mice, significant titers of specific antilaminarin antibodies comparable with those raised by the Lam-CRM197 conjugate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::898cf8f00a947e26d91b40d514a5fa82 https://doi.org/10.1080/07328303.2011.604453 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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