Advances in the Interaction between Intestinal Microbiota and COVID-19
| Autor: | Yun-Xiao Liang, Lian-Ying Cai, Zhi-Jun He |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Coronavirus disease 2019 (COVID-19)
business.industry viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) fungi Pathogenic bacteria Lung injury medicine.disease Systemic inflammation medicine.disease_cause digestive system Virus stomatognathic diseases Flora (microbiology) Immunology medicine medicine.symptom business Dysbiosis |
| Zdroj: | Exploratory Research and Hypothesis in Medicine. :1-8 |
| ISSN: | 2472-0712 |
| Popis: | Coronavirus disease 2019 (COVID-19) is a global epidemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many digestive symptoms have been reported in patients infected with this virus, however, the relationship between the intestinal microbiota and SARS-CoV-2 remains unknown. This review aims to elucidate the interaction between intestinal microbiota and SARS-CoV-2, and review the mechanism of interaction between these two items as well as the effects of probiotics. This review further discusses various studies on gastrointestinal symptoms and changes in intestinal microbiota in COVID-19 patients. To further understand the mechanism, we focused on the role of angiotensin converting enzyme 2 and transmembrane protease serine 2 in this viral infection. There is a correlation between many diseases and dysbiosis of intestinal microbiota. SARS-CoV-2 can lead to dysbiosis of intestinal microbiota through a variety of mechanisms, with a decrease in the abundance and diversity of probiotics and an increase in that of pathogenic bacteria. Dysbiosis of intestinal microbiota results in the translocation of intestinal flora, aggravation of systemic inflammation, and lung injury. Modulating the intestinal microbiota ameliorates digestive symptoms and pathology in infectious respiratory diseases. Intestinal microbiota and SARS-CoV-2 interact through a variety of mechanisms; SARS-CoV-2 can cause dysbiosis of the intestinal microbiota, while dysbiosis of intestinal microbiota, in turn, aggravates COVID-19. |
| Databáze: | OpenAIRE |
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