Effect of oxybutynin on reflex micturition in the decerebrate dog as determined by urodynamic evaluation
| Autor: | Seigi Tsuchida, Keietsu Satoh, Takeo Kohama, Tadashi Harada, Kimio Sugaya, Osamu Nishizawa |
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| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Urology Urethral sphincter media_common.quotation_subject Cystometry Hyperreflexia Urination Detrusor instability Urethral sphincter emg Anesthesia Reflex medicine Neurology (clinical) medicine.symptom Oxybutynin business medicine.drug media_common |
| Zdroj: | Neurourology and Urodynamics. 8:513-519 |
| ISSN: | 1520-6777 0733-2467 |
| DOI: | 10.1002/nau.1930080515 |
| Popis: | The effect of oxybutynin on reflex micturition in the decerebrate dog was investigated by cystometric and striated urethral sphincter EMG studies. Reflex micturition consisting of bladder contraction and relaxation of the striated urethral sphincter occurred when a critical degree of filling was reached in the absence and presence of cumulative doses of 30, 100, and 300 μg/kg of oxybutynin. Oxybutynin at doses of 30, 100, and 300 μg/kg produced a significant increase in threshold volume during the collecting phase in a dose-dependent manner. In the urodynamic parameters of the emptying phase considered to be influenced greatly by cholinergic activity there was a small but significant decrease in the maximum bladder pressure only at a dose of 300 μg/kg. The present study supports urodynamically clinical usefulness of oxybutynin for the relief of symptoms associated with detrusor instability and hyperreflexia. |
| Databáze: | OpenAIRE |
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