The Impact of Atrial Fibrillation Treatment Strategies on Cognitive Function

Autor: Neil Bodagh, Irum Kotadia, Ali Gharaviri, Fernando Zelaya, Jonathan Birns, Ajay Bhalla, Peter Sommerville, Steven Niederer, Mark O’Neill, Steven E. Williams
Rok vydání: 2023
Předmět:
Zdroj: Journal of Clinical Medicine. 12:3050
ISSN: 2077-0383
DOI: 10.3390/jcm12093050
Popis: There is increasing evidence to suggest that atrial fibrillation is associated with a heightened risk of dementia. The mechanism of interaction is unclear. Atrial fibrillation-induced cerebral infarcts, hypoperfusion, systemic inflammation, and anticoagulant therapy-induced cerebral microbleeds, have been proposed to explain the link between these conditions. An understanding of the pathogenesis of atrial fibrillation-associated cognitive decline may enable the development of treatment strategies targeted towards the prevention of dementia in atrial fibrillation patients. The aim of this review is to explore the impact that existing atrial fibrillation treatment strategies may have on cognition and the putative mechanisms linking the two conditions. This review examines how components of the ‘Atrial Fibrillation Better Care pathway’ (stroke risk reduction, rhythm control, rate control, and risk factor management) may influence the trajectory of atrial fibrillation-associated cognitive decline. The requirements for further prospective studies to understand the mechanistic link between atrial fibrillation and dementia and to develop treatment strategies targeted towards the prevention of atrial fibrillation-associated cognitive decline, are highlighted.
Databáze: OpenAIRE
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