Effects of Amla (Phyllanthus embilica L.) Extract on Hair Growth Promoting

Autor:	Seung-Hee Jang, Min-Jeong Kim, Ji-Hyang Wee, Jong-Tae Kim, Won-Hee Choi
Rok vydání:	2018
Předmět:	Phyllanthus integumentary system biology Chemistry VEGF receptors Cell Proliferative Activity Reductase Pharmacology medicine.disease biology.organism_classification Hair growth Dermal papillae medicine.anatomical_structure Hair loss Phyllanthus emblica medicine biology.protein
Zdroj:	KSBB Journal. 33:299-305
ISSN:	2288-8268 1225-7117
DOI:	10.7841/ksbbj.2018.33.4.299
Popis:	This study aimed to determine that amla (Phyllanthus emblica L.) extract prevents and alleviates hair loss. We measured cell proliferative activity, 5alpha- reductase inhibitory, TGF-beta1 and DKK-1, IGF-1 and VEGF effect on human dermal papilla cells to investigate therapeutic effect of the amla extract. The cell proliferative activity in human dermal papilla cells was observed to be most prominent in the range of 50 μg/ml. Also, amla extract decreased the expression of 5alpha-reductase in a dose dependent manner in human dermal papilla cells. And IGF-1 and VEGF which were known to accelerate the differentiation and growth of human dermal papilla cells was increased by amla extract in a dose dependent manner. Taken together, these results suggest that amla extract has hair growth promoting effect and it may be a potent candidate for the prevention of hair loss.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8960ae2eacb7462fc9c7be563ed0e266 https://doi.org/10.7841/ksbbj.2018.33.4.299 Zobrazit plný text záznamu