Ein Oxepan-Derivat des Panaxadiols aus den Blättern von Panax notoginseng
| Autor: | Edmund Friedrichs, Heinrich Puff, Wang Jufen, Chang Liangyu, Chen Wei-Shin, Wei Junxiang, Eberhard Breitmaier |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Chromatography biology Stereochemistry Organic Chemistry Panaxatriol Saponin Pharmaceutical Science Sapogenin biology.organism_classification Analytical Chemistry Oxepane chemistry.chemical_compound Column chromatography Complementary and alternative medicine chemistry Drug Discovery Molecular Medicine Araliaceae Panax notoginseng Derivative (chemistry) |
| Zdroj: | Planta Medica. 50:47-52 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2007-969619 |
| Popis: | Hydrolysis of the crude saponin isolated from the leaves of PANAX NOTOGINSENG (Burk.) F. H. Chen yields five sapogenins which are separated by column chromatography. The structures of four of those were elucidated earlier to be panaxadiol, panaxatriol, dammar-20(22)en-3beta, 12beta,26-triol and 20(R)-dammaran-3beta, 12beta,20,25-tetrol. The fifth sapogenin is identified as an oxepane derivative probably arising from acid catalyzed dehydration and rearrangement of panaxadiol. The structure as proposed from NMR data was confirmed by single-crystal X-ray diffractometry. |
| Databáze: | OpenAIRE |
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