Impaired endothelial- and nonendothelial-mediated vasodilation in patients with acute or chronic hypothyroidism
| Autor: | Emanuela Zarra, Carolina D’Anna, Margherita Matarazzo, Luigi Saccà, Vincenzo Guardasole, Antonietta De Sena, Giovanni Lupoli, Gelsy Arianna Lupoli, Raffaele Napoli, Ugo Oliviero |
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| Rok vydání: | 2010 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Endothelium business.industry Endocrinology Diabetes and Metabolism Thyroid Primary hypothyroidism Vasodilation Nitric oxide chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine medicine Sodium nitroprusside medicine.symptom business Asymmetric dimethylarginine Vasoconstriction medicine.drug |
| Zdroj: | Clinical Endocrinology. 72:107-111 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.2009.03609.x |
| Popis: | Summary Objective Vascular dysfunction and accelerated atherosclerosis are prominent features of hypothyroidism. The relative roles of thyroid hormone (TH) deficiency and the associated vascular risk conditions are still unclear. We studied the impact of acute and chronic hypothyroidism on vascular reactivity. Patients We studied 12 patients with chronic primary hypothyroidism (cHY; TSH: 52 ± 14 mU/l), seven patients with acute hypothyroidism secondary to total thyroidectomy (aHY; TSH: 97 ± 24) and 13 healthy subjects (TSH: 1·2 ± 0·5). Measurements We measured forearm blood flow (FBF) using plethysmography during intra-brachial infusion of: acetylcholine (ACh), sodium nitroprusside (NP) and norepinephrine (NE). We also measured serum C-reactive protein (CRP), TNF-alpha, asymmetric dimethylarginine (ADMA) and the forearm balance of nitric oxide (NO) during ACh infusion. Results As compared with the controls, the vasodilatory response to ACh was reduced in cHY (P = 0·001) and aHY (P = 0·04), as was the forearm release of NO (P |
| Databáze: | OpenAIRE |
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