Collaboration in Natural Product Total Synthesis: Carolacton – A Decade of Discovery

Autor:	Amy E. Solinski, William M. Wuest
Rok vydání:	2020
Předmět:	Carolacton chemistry.chemical_compound Research groups Natural product chemistry 010405 organic chemistry Organic Chemistry Biochemical engineering 010402 general chemistry 01 natural sciences Cellular viability 0104 chemical sciences
Zdroj:	Synlett. 32:241-248
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0040-1707244
Popis:	Carolacton, a macrocyclic natural product with impressive anti-biofilm biological activity, has been a focus in multiple research groups for the past decade. Chemists and biologists, alike, have been interested in uncovering the mechanism of action and have made great strides towards this goal. Carolacton causes cellular defects in Streptococcus mutans biofilm, which leads to decreases in cellular viability. As biological targets have been uncovered, synthetic chemists have devised synthetic routes that have helped uncover the important chemical functionalities that lead to biological activity. Herein, we discuss our synthetic collaboration that galvanized an entire research program around the natural product carolacton.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::894c4944a946e5ee2dc065df10df3ba8 https://doi.org/10.1055/s-0040-1707244 Zobrazit plný text záznamu