Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD
| Autor: | Robert M. Burkes, Agathe S. Ceppe, Claire M. Doerschuk, David Couper, Eric A. Hoffman, Alejandro P. Comellas, R. Graham Barr, Jerry A. Krishnan, Christopher Cooper, Wassim W. Labaki, Victor E. Ortega, J. Michael Wells, Gerard J. Criner, Prescott G. Woodruff, Russell P. Bowler, Cheryl S. Pirozzi, Nadia N. Hansel, Robert A. Wise, Todd T. Brown, M. Bradley Drummond, Neil E. Alexis, Wayne H. Anderson, Mehrdad Arjomandi, Igor Barjaktarevic, Lori A. Bateman, Surya P. Bhatt, Eugene R. Bleecker, Richard C. Boucher, Stephanie A. Christenson, Christopher B. Cooper, David J. Couper, Ronald G. Crystal, Jeffrey L. Curtis, Mark T. Dransfield, Brad Drummond, Christine M. Freeman, Craig Galban, MeiLan K. Han, Annette T. Hastie, Yvonne Huang, Robert J. Kaner, Richard E. Kanner, Eric C. Kleerup, Lisa M. LaVange, Stephen C. Lazarus, Fernando J. Martinez, Deborah A. Meyers, Wendy C. Moore, John D. Newell, Robert Paine, Laura Paulin, Stephen P. Peters, Cheryl Pirozzi, Nirupama Putcha, Elizabeth C. Oelsner, Wanda K. O’Neal, Sanjeev Raman, Stephen I. Rennard, Donald P. Tashkin, Lisa Postow, Lisa Viviano |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
COPD medicine.medical_specialty Exacerbation business.industry Intermediate outcome Critical Care and Intensive Care Medicine medicine.disease vitamin D deficiency respiratory tract diseases Odds Internal medicine Cohort medicine Vitamin D and neurology Cardiology and Cardiovascular Medicine business Lung function |
| Zdroj: | Chest. 157:856-865 |
| ISSN: | 0012-3692 |
| Popis: | Background The relationship between 25-hydroxyvitamin D (25-OH-vitamin D) and COPD outcomes remains unclear. Using the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS), we determined associations among baseline 25-OH-vitamin D and cross-sectional and longitudinal lung function and COPD exacerbations. Methods Serum 25-OH-vitamin D level was measured in stored samples from 1,609 SPIROMICS participants with COPD. 25-OH-vitamin D levels were modeled continuously and dichotomized as deficient ( Results Vitamin D deficiency was present in 21% of the cohort and was more prevalent in the younger, active smokers, and blacks. Vitamin D deficiency was independently associated with lower % predicted FEV1 (by 4.11%) at enrollment (95% CI, –6.90% to –1.34% predicted FEV1; P = .004), 1.27% predicted greater rate of FEV1 decline after 1 year (95% CI, –2.32% to –0.22% predicted/y; P = .02), and higher odds of any COPD exacerbation in the prior year (OR, 1.32; 95% CI, 1.00-1.74; P = .049). Each 10-ng/mL decrease in 25-OH-vitamin D was associated with lower baseline lung function (–1.04% predicted; 95% CI, –1.96% to –0.12% predicted; P = .03) and increased odds of any exacerbation in the year before enrollment (OR, 1.11; 95% CI, 1.01-1.22; P = .04). Conclusions Vitamin D deficiency is associated with worse cross-sectional and longitudinal lung function and increased odds of prior COPD exacerbations. These findings identify 25-OH-vitamin D levels as a potentially useful marker of adverse COPD-related outcomes. |
| Databáze: | OpenAIRE |
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