LEVELS OF IMMUNOGLOBULIN G AND MARKERS OF VASCULAR INFLAMMATORY RESPONSE AS PREDICTORS OF POSSIBLE VASCULAR COMPLICATIONS IN PATIENTS WITH ARTERIAL HYPERTENSION AFTER SARS-COV-2
Autor: | Tatiana Petelina, Musikhina Natalia, Yaroslavskaya Elena, Gultyaeva Elena, Avdeeva Ksenia, Gorbatenko Elena, Gapon Lyudmila, Zueva Ekaterina, Shcherbinina Anastasia |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Creatinine medicine.diagnostic_test biology Physiology business.industry Complete blood count medicine.disease Gastroenterology Immunoglobulin G chemistry.chemical_compound Blood pressure Cystatin C chemistry Internal medicine Internal Medicine medicine biology.protein Creatine kinase medicine.symptom Endothelial dysfunction Cardiology and Cardiovascular Medicine business Abdominal obesity |
Zdroj: | Journal of Hypertension. 39:e394 |
ISSN: | 1473-5598 0263-6352 |
DOI: | 10.1097/01.hjh.0000749132.26688.62 |
Popis: | Objective: To investigate the level and relationship of specific immunoglobulin G (IgG) antibodies to SARS-CoV-2 with laboratory parameters of vascular inflammatory response (VIR) during follow-up of patients with arterial hypertension (AH) in 3 months after disease onset. Design and method: Retrospective, single-center observational study included 76 confirmed cases of COVID-19 associated with pneumonia (April-May 2020). Gr.1 consisted of 32 patients without AH;Gr.2 involved 44 AH patients, including 18 patients with metabolic disorders (abdominal obesity and impaired carbohydrate metabolism). Complete blood count, biochemical and hemostatic parameters were determined on the day of admission. Comprehensive analysis of clinical instrumental and laboratory parameters, including blood pressure, heart rate, IgG (positivity rate), cytokines, NT-pro BNP, endothelial dysfunction markers, cystatin C, glucose and others was performed in 3 months after discharge. Results: In Gr.1, IgG was negatively associated with hemoglobin, red blood cell volume, neutrophils, creatine phosphokinase, homocysteine, those were supplemented by NT-pro BNP, interleukin-6, lactate dehydrogenase, creatinine (p 12.9 with thrombogenic parameters. Conclusions: IgG might be a sensitive indicator of VIR and can play a role in predicting possible unwanted vascular complications in AH patients after suffering from SARS-CoV-2. |
Databáze: | OpenAIRE |
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