Phytochemical screening and toxicological profile of methanolic extract ofPicralima nitidafruit-rind (Apocynaceae)
| Autor: | L.B. Kouitcheu Mabeku, F.X. Etoa, Jacques Kouam, A. Paul |
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| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Toxicological & Environmental Chemistry. 90:815-828 |
| ISSN: | 1029-0486 0277-2248 |
| Popis: | The methanol (M) extract of the fruit-rinds of Picralima nitida (PN) was analyzed phytochemically and evaluated for its toxicity effect in Wistar rats. The rats were administered graded doses (0.75, 1.5, 3, and 6 g kg−1 p.o) of the extract daily for 6 weeks and the toxicological effect of these varying levels of extract were examined on the serum, hepatic, and renal concentration of biochemical parameters as well as the histopathology of tissue section of these liver, kidney, and lungs. Clinical signs and hematology were also evaluated. Phytochemical analysis revealed that alkaloids and polyphenols were major compounds. Both biochemical and histopathological data presented demonstrate dose-dependent signs of toxicity. Our results show a significant elevation in serum concentration of aspartate amino-transferase, alanine amino-transferase, glucose, creatinine, total cholesterol, and protein with high-dose of PN treatment tested. PN also caused a significant reduction in hepatic malondialdehyde and a slight... |
| Databáze: | OpenAIRE |
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