| Autor: |
Ozcan Erel, Mehmet Kilic, Ersin Gürkan Dumlu, Mehmet Tokaç, Ibrahim Kilinc, Mustafa Özsoy, Nazmiye Dincer |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
European Journal of Clinical Medicine. 2:55-59 |
| ISSN: |
2736-5476 |
| DOI: |
10.24018/clinicmed.2021.2.3.83 |
| Popis: |
Introduction: Intestinal ischemia/reperfusion (I/R) is a serious life-threatening clinical case. Overproduction of reactive oxygen species (ROS) associated with oxidative stress plays a key role in I/R pathophysiology. Objective: The aim of this study is to evaluate dynamic thiol / disulfide hemostasis in intestinal I/R in rats. Materials and Methods: 24 Winstar albino rats were divided into 3 groups (8 animals in each group: (1) sham (operation without ischemia), (2) ischemia (90 minutes ischemia), (3) ischemia/reperfusion (after ischemia for 30 minutes reperfusion for 60 minutes). At the end of the process, liver samples were evaluated pathologically. Also, in plasma samples, native thiol, disulphide and total thiol levels were measured. Results: Native thiol levels in ischemia and I/R group were found to be significantly lower compared to the sham group (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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