4-(2-PYRTOYL)-5-phenylthiazoles as novel non-bicyclic reversible inhibitors of the gastric H+/K+-atpase
Autor: | Leach Colin Andrew, Robert John Ife, A.J. Pope, C.J. Theobald |
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Rok vydání: | 1995 |
Předmět: |
Bicyclic molecule
biology Stereochemistry ATPase Organic Chemistry Clinical Biochemistry Quinoline Gastric H+/K+ ATPase Pharmaceutical Science Protonation Biochemistry chemistry.chemical_compound chemistry Drug Discovery Pyridine biology.protein Molecular Medicine Molecule Thiazole Molecular Biology |
Zdroj: | Bioorganic & Medicinal Chemistry Letters. 5:543-546 |
ISSN: | 0960-894X |
Popis: | 4-(2-Pyridyl)-5-phenylthiazoles, 3 (X = S), are shown to be reversible, K + -competitive gastric H + /K + -ATPase inhibitors. It is suggested that a hydrogen-bond between the protonated pyridine and the thiazole may help the molecule adopt a conformation which mimics that of the previously described quinoline based inhibitors such as 1 and 2 . |
Databáze: | OpenAIRE |
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