4-(2-PYRTOYL)-5-phenylthiazoles as novel non-bicyclic reversible inhibitors of the gastric H+/K+-atpase

Autor:	Leach Colin Andrew, Robert John Ife, A.J. Pope, C.J. Theobald
Rok vydání:	1995
Předmět:	Bicyclic molecule biology Stereochemistry ATPase Organic Chemistry Clinical Biochemistry Quinoline Gastric H+/K+ ATPase Pharmaceutical Science Protonation Biochemistry chemistry.chemical_compound chemistry Drug Discovery Pyridine biology.protein Molecular Medicine Molecule Thiazole Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:543-546
ISSN:	0960-894X
Popis:	4-(2-Pyridyl)-5-phenylthiazoles, 3 (X = S), are shown to be reversible, K + -competitive gastric H + /K + -ATPase inhibitors. It is suggested that a hydrogen-bond between the protonated pyridine and the thiazole may help the molecule adopt a conformation which mimics that of the previously described quinoline based inhibitors such as 1 and 2 .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::892fefddc4abcb38a216d6a5c164bc99 https://doi.org/10.1016/0960-894x(95)00069-6 Zobrazit plný text záznamu Full Text from ScienceDirect