DOES ESTROGEN SUBSTITUTION MATERIALLY INHIBIT PITUITARY GONADOTROPIC POTENCY?1,2
| Autor: | Elmer L. Sevringhaus, Emily J. Heller, Carl G. Hisaw |
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| Rok vydání: | 1942 |
| Předmět: | |
| Zdroj: | Endocrinology. 30:309-316 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-30-2-309 |
| Popis: | THAT SMALL DOSES of estrogens may exert a profound influence upon the mammalian organism without materially depressing the gonadotropic action of the J L pituitary gland has been previously reported from this laboratory (1, 2). Our initial interest in the relationship between the gonads and the pituitary gland was aroused by the generally accepted belief that the gonadotropic action of the pituitary gland is entirely regulated by the secretions of the gonads, and more specifically, that the estrogenic hormones exert an inhibitory or depressant effect upon the gonadotropic action of the hypophysis. When crystalline estradiol was made available to us early in 1937,4 an attempt was made to quantitate this relationship by treating castrated rats with graduated doses of estradiol, and later evaluating the effect by assaying the pituitary glands from these animals. In this effort we had a number of advantages contributing to the accuracy of the experiment that the earlier workers in the field did not have. |
| Databáze: | OpenAIRE |
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