Characterization of DDRI-18 (3,3′-(1H,3′H-5,5′-bibenzo[d]imidazole-2,2′-diyl)dianiline), a novel small molecule inhibitor modulating the DNA damage response

Autor:	Jun Dw, Sun-Whe Kim, Jeong Ys, Choong Hwan Lee, Hyunyong Kim, Jeong Kc
Rok vydání:	2012
Předmět:	Pharmacology DNA repair DNA damage Stereochemistry Biology Bleomycin Molecular biology Small molecule body regions chemistry.chemical_compound Biomarker chemistry medicine Imidazole Camptothecin Etoposide medicine.drug
Zdroj:	British Journal of Pharmacology. 167:141-150
ISSN:	0007-1188
Popis:	BACKGROUND AND PURPOSE Recently, the DNA damage response (DDR) has emerged as a promising target for anticancer drug development. In our previous study, we identified several DDR-inhibiting compounds via high-content screening of a small molecule library using γH2AX foci as a biomarker. Here, we studied the effects of the DNA damage response inhibitor DDRI-18 (3,3′-(1H,3′H-5,5′-bibenzo[d]imidazole-2,2′-diyl)dianiline) on DDR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::89121d37a8190f97c0e6254c62d9141b https://doi.org/10.1111/j.1476-5381.2012.01977.x Zobrazit plný text záznamu Plný text