HPV Positivity and Risk of Cervical Cancer according to HIV-Infection: A Comparative Assessment in the Population of Cameroonian Women

Autor: Nadine Fainguem, Alexis Ndjolo, Achille Nange, Ezechiel Ngoufack Jagni Semengue, Michel Carlos Tommo Tchouaket, Judith N. Torimiro, Aissatou Abba, Joseph Fokam, Aline Tiga, Samuel Martin Sosso, Rachel Kamgaing Simo, Georgia Ambada, Elise Elong Lobe, Alex Durand Nka, Serge Clotaire Billong, Zacharie Sando, Bouba Yagai, Aude Christelle Ka'e, V. Colizzi, Marie Krystel Nnomo Zam, Collins Chenwi, Valère Tala
Rok vydání: 2021
Předmět:
DOI: 10.21203/rs.3.rs-279543/v1
Popis: Background Cervical cancer, caused by the human papillomavirus (HPV), remains a global health challenge. In HIV highly-burdened settings, it would be relevant to understand the severity of cervical cancer in case of co-infection with HPV. We therefore sought to determine the effect of HPV on the occurrence of cervical lesions among women with versus without HIV-infection. Methods A cross-sectional analytical study was conducted throughout 2012 among 257 women living in Yaoundé, Cameroon. HIV serology, genotyping of high-risk oncogenic HPV and cervical vaginal smear (CVS) were performed for all participants; among those reported to be HIV seropositive, HIV plasma viral load and CD4 count were measured. Results of the CVS were interpreted following the Bethesda 2001 guidelines. Statistical analyses were performed using Graph Pad version 6.0; p 3 and median viremia
Databáze: OpenAIRE