Synthesis of 2,6-disubstituted and 2,3,6-trisubstituted anilines

Autor:	Richard M. Wehmeyer, R. Garth Pews, James E. Hunter
Rok vydání:	1993
Předmět:	Steric effects Organic Chemistry Halogenation Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Drug Discovery Electronic effect Organic chemistry Amine gas treating Formate Selectivity Protecting group
Zdroj:	Tetrahedron. 49:4809-4820
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)80400-2
Popis:	A number of 2,6-disubstituted and 2,3,6-trisubstituted anilines have been prepared via the selective para dehalogenation of the corresponding anilines. Modification of the substituents on the amino nitrogen demonstrates that the selectivity is derived from steric rather than electronic effects. The effects of the choice of formate hydrogen donor, Pd catalyst, solvent, and temperature upon the efficiency and selectivity of the dehalogenation are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::88ef0964b912029618523c89d8d5aa5b https://doi.org/10.1016/s0040-4020(01)80400-2 Zobrazit plný text záznamu