BNP and NT-proBNP Assays for Heart-Failure Diagnosis in Patients With Cerebral Infarction
| Autor: | Yuanlong Yu, Minghuan Suo, Weijia Wang, Youye Yang, Haizhong Yan, Fei Li, Lijuan Kan, Dongmei Wen, Xiuming Zhang, Qian Wang, Nengliang Ouyang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
business.industry Cerebral infarction Biochemistry (medical) Clinical Biochemistry Central nervous system Renal function medicine.disease University hospital Brain natriuretic peptide medicine.anatomical_structure Internal medicine Heart failure Acute cerebral infarction cardiovascular system medicine Cardiology In patient cardiovascular diseases business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Laboratory Medicine. 44:46-50 |
| ISSN: | 1943-7730 0007-5027 |
| DOI: | 10.1309/lmpeazf6uyu8fg4h |
| Popis: | Objective To determine whether BNP or NT-proBNP levels more strongly indicate or predict cardiac diseases in patients with chronic heart failure, cerebral infarction, cerebral hemorrhage, and acute cerebral infarction complicated with heart failure. Methods A total of 303 patients aged 33 to 80 years with chronic heart failure, acute cerebral infarction, cerebral hemorrhage, or acute cerebral infarction complicated with heart failure were consecutively recruited in a university hospital. Their heart failure stages I to III (equivalent to grades II to IV) were classified according to American College of Cardiology Foundation/American Heart Association guidelines for adults. Results Mean NT-proBNP and BNP concentrations in the patients with acute cerebral infarction or heart failure were significantly higher than those of the controls (mean [SD] NT-proBNP levels, 1132.27 [106.54] ng/L in patients with acute cerebral infarction and 3217.12 [369.19] ng/L in patients with heart failure). However, the levels of BNP and NT-proBNP were not statistically different between the cerebral hemorrhage and control groups ( P > .05). Conclusions Continuous monitoring of NT-proBNP levels in patients with acute cerebral infarction complicated with heart failure may be more helpful in determining correct diagnoses. Also, because BNP levels vary much less than those of NT-proBNP, the former better reflect the actual condition of heart failure in acute cerebral infarction complicated with heart failure compared with the latter. * BNP : brain natriuretic peptide aa : amino acid(s) mRNA : messenger RNA ACCF : American College of Cardiology Foundation GFR : glomerular filtration rate EDTA : ethylenediaminetetraacetic acid CNS : central nervous system |
| Databáze: | OpenAIRE |
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