ChemInform Abstract: Synthesis and Pharmacological Studies on Some Phthalimidoxy Substituted Quinoline Derivatives

Autor:	Chirag Sharma, Vijay K. Salvi, G. L. Talesara, Dinesh Bhambi, Devendra K. Sain
Rok vydání:	2010
Předmět:	Phthalimide chemistry.chemical_compound chemistry Yield (chemistry) Quinoline Hydrazine Alkoxy group Organic chemistry General Medicine Hydrazide Hydrate Acetamide
Zdroj:	ChemInform. 41
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.201016129
Popis:	Synthesis of novel N'-[2-(4-substitutedphenyl)-3-N-ethoxyphthalimido-5-oxoimidazolidene-1-yl]-2-(quinoline-8-yloxy)acetamide derivatives (6a-e) with potential biological activities were carried out by adopting the reaction scheme given below. Compound ethyl-(quinoline-8-yloxy)acetate (2) was synthesized by refluxing 8-hydroxyquinoline with ethylchloroacetate in presence of K 2 CO 3 . Ethyl-(quinoline-8-yloxy)acetate (2) was converted to corresponding hydrazide (3) on treatment with hydrazine hydrate which on further condensation with various araldehydes gave respective Schiff's bases (4a-e). These on cyclisation with glycine yielded corresponding oxoimidazolidenes (5a-e). Active H of imidazolidinones (5a-e) was replaced by ethoxy phthalimide to yield final products (6a-e).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::88e8d56cac344afe61c2e1199b4236f2 https://doi.org/10.1002/chin.201016129 Zobrazit plný text záznamu Plný text