Deletion disrupts a conserved antibody epitope in a SARS-CoV-2 variant of concern

Autor:	Sham Nambulli, Linda L. Rennick, Lindsey R. Robinson-McCarthy, Kevin R. McCarthy, W. Paul Duprex
Rok vydání:	2021
Předmět:	Genetics Antigenicity Immune system Lineage (genetic) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Antigenic variation biology.protein Biology Antibody Viral resistance Epitope
Popis:	Multiple SARS-CoV-2 variants with altered antigenicity have emerged and spread internationally. In one lineage of global concern, we identify a transmitted variant with a deletion in its receptor binding domain (RBD) that disrupts an epitope which is conserved across sarbecoviruses. Overcoming antigenic variation by selectively focusing immune pressure on this conserved site may, ultimately, drive viral resistance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::88e0cae4bbcb1f06fb21a855121193a0 https://doi.org/10.1101/2021.03.05.434168 Zobrazit plný text záznamu