Depressed Gut Absorptive Capacity Early After Trauma-Hemorrhagic Shock G. SINGH, K. I. CHAUDRY, L. C. CHUDLER, AND I. H. CHAUDRY Annals of Surgery 214:712-718, 1991
| Autor: | Michael S. Nussbaum |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Resuscitation Mean arterial pressure Nutrition and Dietetics business.industry medicine.medical_treatment Medicine (miscellaneous) Blood volume Arterial catheter Intestinal absorption Surgery Anesthesia Shock (circulatory) medicine Diltiazem medicine.symptom business Saline medicine.drug |
| Zdroj: | Journal of Parenteral and Enteral Nutrition. 16:397-398 |
| ISSN: | 1941-2444 0148-6071 |
| Popis: | The authors investigated the effect of the calcium channel antagonist diltiazem on gut absorptive capacity after hemorrhage in rats. Carotid and femoral arterial catheters, portal and jugular venous catheters, and nasogastric tubes were placed in 12 anesthetized animals. After recovery from the anesthetic, eight animals (groups 2 and 3) were bled via the femoral catheter to a mean arterial pressure (MAP) of 40 mm Hg. This level of hypotension was maintained by continued bleeding to the maximal bleedout volume (approximately 60% of the animal's circulating blood volume), followed by infusion of lactated Ringer's solution until 40% of the maximal bleedout volume had been returned. The animals were then resuscitated with lactated Ringer's solution. Four rats (group 1) were not hemorrhaged and served as sham controls. During resuscitation the animals in group 2 received an additional 1 mL of saline, whereas those in group 3 were treated with diltiazem 400 μg/kg body weight in 1 mL of saline. MAP was measured ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text