Immunohistochemical evaluation of positive hormone receptors and HER2 overexpression in women with breast cancer
| Autor: | Botan A Ali, Ahmed Abdulkadir Baban, Tamara Abdul Ezel Al-Mufty, Zakarea Ay Al-Khayat |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty education.field_of_study Pathology medicine.drug_class business.industry Population Estrogen receptor medicine.disease medicine.anatomical_structure Breast cancer Estrogen Hormone receptor Internal medicine medicine Immunohistochemistry skin and connective tissue diseases education business Receptor Lymph node |
| Zdroj: | Ibnosina Journal of Medicine and Biomedical Sciences. :168-175 |
| ISSN: | 1947-489X |
| Popis: | Background: Breast cancer has a tremendousheterogeneity in its clinical behavior. The objective of this study is to assess the positive expression of estrogen receptors (ER), progesterone receptors (PR)and HER2 overexpression in relationship with the age of patients, and certain prognostic parameters suchas tumor grade, size and lymph node involvement. Patients and methods: A cross sectional case studywas conducted between June 2011 and June 2014 atthe pathology department of Rizgary General Hospital,Erbil, Iraq. 114 Confirmed cases of breast cancer werestudied. Immunohistochemistry was used to evaluatethe expression of ER, PR and HER2 status. Patients’mean age was 48±5 (Range: 28-83) years; 57% ofthem were ≤50 years. Results: The expression of ER and PR was 58.8% and 49.1% respectively. HER2overexpression (score +3) was 29.8%. Hormonereceptors (ER and PR) correlated significantly with ageand grade of the tumor whereas HER2 overexpressioncorrelated significantly with grade and lymph nodeinvolvement. An inverse correlation was observedbetween the distribution of both ER & PR andoverexpression of HER2. Conclusions: Expression ofhormone receptors were evident in about half while HER2 overexpression was observed in less than onethird of patients in our population. Different andcommon correlations were observed between ER, PRand HER2 expression and other patient and tumorcharacteristics. HER2 overexpression is associatedwith an aggressive form of breast cancer with highhistological grade and negative ER status. Key words: Immunohistochemistry, Estrogen,Progesterone, HER2, Breast cancer. |
| Databáze: | OpenAIRE |
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