Novel electrochemical method for detection of cytotoxic Tinidazole in aqueous media
| Autor: | Sivakumar Musuvadhi Babulal, Shen-Ming Chen, Alagarsamy Periyalagan, Krishnapandi Alagumalai, Ragurethinam Shanmugam |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
021110 strategic
defence & security studies Environmental Engineering Nitroimidazole General Chemical Engineering 0211 other engineering and technologies 02 engineering and technology 010501 environmental sciences engineering.material Electrocatalyst Electrochemistry 01 natural sciences Combinatorial chemistry Tinidazole chemistry.chemical_compound chemistry Electrode engineering medicine Environmental Chemistry Surface modification Noble metal Safety Risk Reliability and Quality Cobalt oxide 0105 earth and related environmental sciences medicine.drug |
| Zdroj: | Process Safety and Environmental Protection. 148:992-1005 |
| ISSN: | 0957-5820 |
| Popis: | Antibiotics drugs are essential pharmaceutical compounds that play a vital role in the pharmaceutical industry, hospital, and livestock farming. The large scale of pharmaceutical and husbandry effluents are the primary environmental pollutants in water bodies. Even low concentrations of toxic nitroimidazole residues could lead to severe issues for humans and aquatic environments. Simultaneously, electrochemical sensing of cytotoxic antibiotics provides a critical assurance in quality control laboratories, pharmaceutical industries, and in environment pollutant assessment. The electrode surface modification with an excellent electrocatalyst paves the way for the effective determination of these cytotoxic antibiotics. Herein, Noble metal silver incorporated carrom coin structured cobalt oxide (Ag-Co3O4 NPs) was synthesized through a simple co-precipitation technique, and its electrocatalytic actives sites were improved via calcination at 600 °C. The modified electrodes were implemented in the electrochemical detection of cytotoxic Tinidazole (TNZ). The electrochemical characterization shows low charge transfer resistance (Rct) and prominent electrochemical active surface area (ECSA). Due to its unique properties, Ag-Co3O4 NPs modified glassy carbon electrode (GCE) exhibits excellent sensitivity, stability, reproducibility, and low detection level up to the Nanomolar scale. Further, it also provides excellent selectivity among other interfering drugs and species. Meanwhile, it paves strategies for the real-time monitoring of TNZ in biological, pharmaceutical, livestock and various wastewater samples which could paves way for effective application in electrochemical sensors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect