| Popis: |
The tendon transmits the skeletal muscle-generated forces to bones and drives the joint motion. While extensive research has indicated the fundamental role of mechanical forces in tendon development during embryonic and postnatal phases, a comprehensive summary regarding the mechanical forces applied to tendons is lacking. This scoping review aimed to summarize the current knowledge regarding the effect of mechanical forces on tendon development. The electronic database search using PubMed was performed in October 2021 and yielded 586 articles, of which 16 articles met the prespecified inclusion criteria. We defined the mechanical force in terms of muscle existence, muscle contraction, or weight-bearing locomotion and identified methodological heterogeneity in applying mechanical force to tendons. Despite the lack of consensus regarding standard intervention methods, the majority of the mechanical interventions were used to regulate the expression or synthesis of well-known growth factors required for tendon development, especially the Scx expression. Our results provide a novel point of view to build future research about mechanobiology in tendon development. |
