Composite iron oxide–Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors
| Autor: | Rohan Fernandes, Anthony Tuesca, Raymond W. Sze, Shraddha S Kale, J. Anand Subramony, Zungho Zun, Elizabeth E. Sweeney, Rachel A. Burga |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Composite number Biophysics Iron oxide Pharmaceutical Science Nanoparticle Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials chemistry.chemical_compound Nuclear magnetic resonance In vivo Drug Discovery T1 weighted medicine Prussian blue medicine.diagnostic_test Organic Chemistry Magnetic resonance imaging General Medicine Photothermal therapy 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry 0210 nano-technology Biomedical engineering |
| Zdroj: | International Journal of Nanomedicine. 12:6413-6424 |
| ISSN: | 1178-2013 |
| Popis: | Theranostic nanoparticles offer the potential for mixing and matching disparate diagnostic and therapeutic functionalities within a single nanoparticle for the personalized treatment of diseases. In this article, we present composite iron oxide-gadolinium-containing Prussian blue nanoparticles (Fe3O4@GdPB) as a novel theranostic agent for T1-weighted magnetic resonance imaging (MRI) and photothermal therapy (PTT) of tumors. These particles combine the well-described properties and safety profiles of the constituent Fe3O4 nanoparticles and gadolinium-containing Prussian blue nanoparticles. The Fe3O4@GdPB nanoparticles function both as effective MRI contrast agents and PTT agents as determined by characterizing studies performed in vitro and retain their properties in the presence of cells. Importantly, the Fe3O4@GdPB nanoparticles function as effective MRI contrast agents in vivo by increasing signal:noise ratios in T1-weighted scans of tumors and as effective PTT agents in vivo by decreasing tumor growth rates and increasing survival in an animal model of neuroblastoma. These findings demonstrate the potential of the Fe3O4@GdPB nanoparticles to function as effective theranostic agents. |
| Databáze: | OpenAIRE |
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