Histopathological and immunohistochemical study of lymphnodal biopsies
| Autor: | Chaitra B, Ramya Potti, Garima B, Venkata Renuka Inuganti, Durga Prasad B |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.diagnostic_test business.industry H&E stain Lymph node biopsy medicine.disease Tuberculous lymphadenitis Lymphoma 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Cytopathology 030220 oncology & carcinogenesis medicine Histopathology 030212 general & internal medicine Lymph business Lymph node |
| Zdroj: | IP Archives of Cytology and Histopathology Research. 5:70-74 |
| ISSN: | 2456-9267 2581-5725 |
| Popis: | Introduction: Diseases affecting lymph nodes form a wide range of spectrum, from simple infection to malignant pathology. A panel of IHC markers is decided based on morphologic differential diagnosis. Aims and Objectives: To study the incidence of lymph nodal lesions with respect to age and sex and their different histopathological patterns. To use Immunohistochemistry (IHC) for sub typing of neoplastic lesions. Materials and Methods: This study was done for a period of two and a half years in the Department o f Pathology, from Jan 2017 to June 2019. All the specimens received were fixed in 10% formalin and routinely processed and stained with Hematoxylin and Eosin (H&E.) Results: A total of 230 lymph node biopsies were studied. Age distribution varied from 3 to 83 years with female preponderance. Non – Neoplastic lesions were common comprising of 120 cases (52%) while neoplastic lesions were 110 (48%). Among non neoplastic lesions reactive lymphadenitis (23%) was common followed by tuberculous lymphadenitis (21%). In neoplastic lesions, metastatic diseases (20%) predominated. IHC was done wherever necessary for subtyping of lymphomas and also to differentiate lymphoma from carcinoma. Conclusion: Lymph node biopsy with IHC plays an important role in establishing the cause for lymphadenopathy and thus aids in therapy. Keywords: Lymph node, Immunohistochemistry, Non-neoplastic, Neoplastic. |
| Databáze: | OpenAIRE |
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