The effect of size and aspect ratio of Fe-MIL-88B-NH2 metal-organic frameworks on their relaxivity and contrast enhancement properties in MRI: in vitro and in vivo studies
| Autor: | Soheila Haghgoo, Nader Riahi Alam, Shahriar Shahriarian, Azadeh Golmohamadpour, Tohid Mortezazadeh, Behnam Majidi, Sadegh Dehghani, Mehdi Khoobi |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Biocompatibility media_common.quotation_subject MRI contrast agent Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Nuclear magnetic resonance In vivo medicine Contrast (vision) General Materials Science media_common Aqueous solution General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics medicine.disease Atomic and Molecular Physics and Optics Hemolysis 0104 chemical sciences Modeling and Simulation Particle size 0210 nano-technology Selectivity |
| Zdroj: | Journal of Nanoparticle Research. 20 |
| ISSN: | 1572-896X 1388-0764 |
| DOI: | 10.1007/s11051-018-4376-2 |
| Popis: | Metal-organic frameworks (MOFs) have shown a great potential as a novel contrast agent in magnetic resonance imaging (MRI) due to their unique properties including versatile structures, composition, and surface chemistry. Fe-MIL-88B-NH2 (MILs) was synthesized using Fe+3 ions and 2-aminoterephthalic acids (NH2-BDC) in the presence of acetic acid and Pluronic F127 under a hydrothermal process. Three MILs in different sizes were synthesized by using variant CH3COOH/Fe+3 molar ratios and denoted as MIL-S, MIL-M, and MIL-L having average sizes of 60, 350, and 730 nm, respectively. The effect of aspect ratio and particle size of MILs was investigated on proton relaxivity and contrast enhancement in aqueous, in vitro, and in vivo MR images. MRI study indicated that by increasing the MILs size, the incremental transverse relaxivity was achieved from 13.53 to 50.80 for r2 and from 38.75 to 60.25 for r2*, while the difference between r2 and r2* was decreased obviously. The r2/r1 ratios were found to be 5.80, 42.27, and 127.00 for MIL-S, MIL-M, and MIL-L, respectively. All MILs demonstrated T2-weighted MR imaging performance. Furthermore, no susceptibility artifacts were observed on T2-weighted images of MILs. By decreasing the size of MILs, r2/r1 ratio was reduced sharply and T1 contrast was also observed for MIL-S. MIL-S was used for in vitro and in vivo study due to its capability in simultaneous T1 and T2 contrast enhancements. MTT and hemolysis assays showed no significant cytotoxicity and hemolysis for MIL-S against normal human breast cell line (MCF-10A) and red blood cells, respectively, at concentrations of Fe+3 up to 300 μg/mL (p |
| Databáze: | OpenAIRE |
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