Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein–RNA Complexes: An Avenue for Discovering New Drugs
| Autor: | Anna K. H. Hirsch, Rita Nasti, Simona Collina, Alessia Pascale, M. Yagiz Unver, Daniela Rossi, Marialaura Amadio |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genetics AU-rich element Messenger RNA 030102 biochemistry & molecular biology RNA Computational biology Biology DNA-binding protein Embryonic stem cell 03 medical and health sciences 030104 developmental biology Docking (molecular) Drug Discovery Gene expression Molecular Medicine Abnormal Vision |
| Zdroj: | Journal of Medicinal Chemistry. 60:8257-8267 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/acs.jmedchem.6b01871 |
| Popis: | RNA-binding proteins play a key role in post-transcriptional processes. Among these proteins, embryonic lethal abnormal vision (ELAV) proteins are among the best described. ELAV proteins predominantly act as positive regulators of gene expression, and their dysregulation is involved in several pathologies, such as cancer, inflammation, and neurodegenerative diseases. Only a few structurally unrelated compounds interfering with ELAV protein–mRNA complexes have been identified by applying high-throughput screening approaches. Considering the structural diversity of the compounds discovered so far and the different techniques employed for screening their ability to interfere with ELAV protein–mRNA complexes, drawing conclusions from structure–activity relationships remains a challenge. We performed docking studies to understand the interactions of compounds reported over the past decade to be inhibitors of ELAV proteins and to evaluate the potential of computer-aided drug design to target this family of prot... |
| Databáze: | OpenAIRE |
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