Synthetic studies of carzinophilin. Part 1: Synthesis of 2-methylidene-1-azabicyclo[3.1.0]hexane systems related to carzinophilin

Autor:	Miyoko Matsumoto, Shiro Terashima, Masaru Hashimoto
Rok vydání:	2003
Předmět:	Hexane chemistry.chemical_classification chemistry.chemical_compound chemistry Sulfide Organic Chemistry Drug Discovery Ethyl nitroacetate Organic chemistry Aziridine Carzinophilin Biochemistry
Zdroj:	Tetrahedron. 59:3019-3040
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(03)00377-6
Popis:	Synthesis of the model compounds of carzinophilin carrying 2-methylidene-1-aza-bicyclo[3.1.0]hexane systems was achieved. Formation of malonylidenes or N-acyl-glycinylidenepyrrolidines was carried out by utilizing Eschenmoser's sulfide contraction or Herdeis's condensation between the 2-methylthio-Δ1-pyrrolone derivatives and ethyl nitroacetate, respectively. The 1-azabicyclo-[3.1.0]hexane systems were constructed by base-promoted aziridine formation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::88a66107bb1fcd23fa79f61e04932dff https://doi.org/10.1016/s0040-4020(03)00377-6 Zobrazit plný text záznamu Full Text from ScienceDirect