DISCREPANCIES BETWEEN PHYSIOLOGICAL AND PHARMACOLOGICAL TESTS OF GROWTH HORMONE (GH) SECRETION IN CHILDREN WITH BRAIN TUMOURS (BT)

Autor:	David R Matthews, P. C. Hindmarsh, H A Spoudeas
Rok vydání:	1993
Předmět:	medicine.medical_specialty Chemotherapy business.industry medicine.medical_treatment Low dose Growth hormone Growth hormone secretion Endocrinology Somatostatin Internal medicine Pediatrics Perinatology and Child Health Medicine Distribution method business Dexamethasone medicine.drug
Zdroj:	Pediatric Research. 33:S27-S27
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-199305001-00142
Popis:	We have performed a mixed longitudinal study of 59 spontaneous (24hr profiles) and stimulated (insulin-induced hypoglycaemia tests - ITT) measures of growth hormone (GH) secretion in 35 prepubertal children aged 1.5 to 11.2 years with BT distant from the hypothalamo-pituitary area before and at 6-12 monthly intervals up to 3 years after surgery ± radiotherapy ± chemotherapy. We have compared results with those obtained in 26 short normal controls (SN). The profiles were analysed by a distribution method. We observed discrepancies between peaks of spontaneous and stimulated GH in BT but not SN. The ratio was significantly greater in all BT groups compared to SN (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8896d3463df7727cba31defe616060c3 https://doi.org/10.1203/00006450-199305001-00142 Zobrazit plný text záznamu